Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function

Resource type
Authors/contributors
Title
Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function
Abstract
The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. We have now come closer to describing such a link by taking the direction of synaptic transmission into account, constructing graphs of a network that reflect the direction of information flow, and analyzing these directed graphs using algebraic topology. Applying this approach to a local network of neurons in the neocortex revealed a remarkably intricate and previously unseen topology of synaptic connectivity. The synaptic network contains an abundance of cliques of neurons bound into cavities that guide the emergence of correlated activity. In response to stimuli, correlated activity binds synaptically connected neurons into functional cliques and cavities that evolve in a stereotypical sequence towards peak complexity. We propose that the brain processes stimuli by forming increasingly complex functional cliques and cavities.
Publication
Frontiers in Computational Neuroscience
Volume
11
Date
2017
Journal Abbr
Front. Comput. Neurosci.
Language
English
DOI
10/gdjbfn
ISSN
1662-5188
Accessed
2019-11-22T20:14:19Z
Library Catalog
Frontiers
Extra
ZSCC: 0000130
Citation
Hess, K., Reimann, M. W., Nolte, M., Scolamiero, M., Turner, K., Perin, R., … Markram, H. (2017). Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function. Frontiers in Computational Neuroscience, 11. https://doi.org/10/gdjbfn
BIOLOGY, NEUROSCIENCE & PSYCHOLOGY
Processing time: 0.02 seconds

Graph of references

(from Zotero to Gephi via Zotnet with this script)
Graph of references